Alternatives to Discontinued OpenAI Assistants API

The most widely-used framework for building LLM-powered applications, available in Python and JavaScript. Provides abstractions for chains, agents, RAG, memory, tool usage, and structured output. Integrates with 100+ LLM providers, vector stores, document loaders, and tools. LangSmith offers tracing and evaluation. LangGraph enables stateful, multi-agent workflows with cycles. 100K+ GitHub stars. The de facto standard for LLM application development despite growing alternatives like LlamaIndex.

Leading Python framework for building LLM-powered applications with focus on data-aware and agentic workflows. Provides tools for RAG (Retrieval-Augmented Generation), document indexing, vector store integrations, query engines, and multi-agent orchestration. 150+ data connectors for various sources. Works with OpenAI, Anthropic, local models, and more. Includes LlamaHub for community tools and LlamaCloud for managed RAG pipelines. 50K+ GitHub stars.

Open-source TypeScript toolkit by Vercel for building AI-powered apps with streaming chat UIs, structured outputs, tool calling, and agent workflows. Framework-agnostic core with integrations for React, Next.js, Svelte, Vue, and Nuxt. Supports a broad AI SDK v6 provider catalog including OpenAI, Anthropic, Google, xAI, Mistral, Bedrock, Groq, and OpenAI-compatible providers. Includes useChat and useCompletion hooks for rapid UI development. The standard SDK for adding AI features to web apps.