Agent Lightning

Framework for LLM applications

The most widely-used framework for building LLM-powered applications, available in Python and JavaScript. Provides abstractions for chains, agents, RAG, memory, tool usage, and structured output. Integrates with 100+ LLM providers, vector stores, document loaders, and tools. LangSmith offers tracing and evaluation. LangGraph enables stateful, multi-agent workflows with cycles. 100K+ GitHub stars. The de facto standard for LLM application development despite growing alternatives like LlamaIndex.

Microsoft's conversational multi-agent framework

AutoGen is an open-source programming framework from Microsoft Research for building AI agents and facilitating cooperation among multiple agents to solve complex tasks through multi-turn conversations. Pioneered conversable agents that interact, use tools, and involve humans in the loop for multi-agent workflows. v0.4 features a redesigned async event-driven architecture with stronger observability, flexible collaboration patterns, and reusable components.

Multi-agent AI framework

Python framework for orchestrating autonomous AI agents that collaborate to accomplish complex tasks. Define agents with specific roles, goals, and backstories, then organize them into crews with sequential or parallel task execution. Supports tool usage (web search, file I/O, API calls), memory, delegation between agents, and human-in-the-loop input. Works with OpenAI, Anthropic, local models, and more. 25K+ GitHub stars. Leading multi-agent framework alongside LangGraph and AutoGen.

Stateful agent orchestration framework by LangChain

LangGraph is LangChain's framework for building stateful, multi-actor AI agent applications as controllable graphs. It models workflows as nodes and edges, enabling cycles, branching, and human-in-the-loop patterns that simple chains cannot express. Features built-in persistence for conversation memory, streaming support, and fault tolerance. Provides fine-grained control over execution flow while supporting single-agent and multi-agent architectures with shared or independent state.

Official Python SDK for OpenAI agents

OpenAI's Python framework for building multi-agent AI applications with GPT models. Provides primitives for creating agents with tool calling, handoffs between specialized agents, guardrails for input/output validation, and tracing for observability. Supports building complex workflows where agents collaborate on tasks. Includes built-in tools for file search, code execution, and web browsing. Designed for production agent systems with structured output and error recovery patterns.